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Semaglutide

Semaglutide is a class of medications, specifically glucagon-like peptide-1 receptor agonists (GLP-1 RAs), commonly used to manage type 2 diabetes and increasingly recognized for their effectiveness in promoting weight loss. These drugs mimic the actions of natural hormones in the body, regulating blood sugar levels and curbing appetite.

Important safety information

Important Safety Information

 

COMPOUNDED SEMAGLUTIDE is a glucagon-like peptide-1 (GLP-1) receptor agonist indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:

27 kg/m² or greater (overweight or obesity)

 

Limitations of Use:

  • Co-administration with other COMPOUNDED SEMAGLUTIDE-containing products or any GLP-1 receptor agonist is not recommended.
  • The safety and efficacy of coadministration with other products for weight management have not been established.
  • COMPOUNDED SEMAGLUTIDE has not been studied in patients with a history of pancreatitis.

     

WARNING: RISK OF THYROID C-CELL TUMORS

  • In rodents, semaglutide causes thyroid C-cell tumors in clinically relevant exposures. It is unknown whether semaglutide causes thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), in humans, as the human relevance of semaglutide-induced rodent thyroid C-cell tumors has not been determined.
  • Semaglutide is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Counsel patients regarding the potential risk of MTC and symptoms of thyroid tumors.

     

Do not take COMPOUNDED SEMAGLUTIDE if you:

  • Have a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
  • Have been diagnosed with pancreatitis or have a history of pancreatitis.
  • Are allergic to semaglutide or any other GLP-1 drug or any of its inactive ingredients.
  • Have a history of suicidal attempts or active suicidal ideation.

     

WARNINGS AND PRECAUTIONS:

  • Acute Pancreatitis: Has occurred in clinical trials. Discontinue promptly if pancreatitis is suspected. Do not restart if pancreatitis is confirmed.
  • Acute Gallbladder Disease: Gallbladder issues have been observed in clinical trials. Clinical follow-up is needed if cholelithiasis is suspected.
  • Hypoglycemia: The use of insulin secretagogues or insulin may increase the risk of hypoglycemia, including severe cases. Adjust the dose of insulin secretagogues or insulin accordingly.
  • Acute Kidney Injury: Monitor renal function when starting or escalating doses in patients reporting severe gastrointestinal side effects.
  • Hypersensitivity Reactions: Anaphylaxis and angioedema have been reported post-marketing. Discontinue if suspected.
  • Pregnancy: Semaglutide may cause fetal harm. Discontinue immediately upon pregnancy recognition.
  • Diabetic Retinopathy Complications: Monitor patients with a history of diabetic retinopathy.
  • Heart Rate Increase: Monitor heart rate periodically.
  • Suicidal Behavior and Ideation: Monitor for signs of depression or suicidal thoughts. Discontinue if these symptoms develop.

     

Side Effects: Most common side effects (incidence ≥ 5%) include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Abdominal pain
  • Fatigue
  • Dyspepsia (indigestion)
  • Dizziness
  • Abdominal distension
  • GERD (gastroesophageal reflux disease)
  • Headache

     

Drug Interactions: COMPOUNDED SEMAGLUTIDE delays gastric emptying, which may impact the absorption of oral medications. Use with caution.

  • Lowers A1C Levels
  • Helps you feel full faster, longer
  • Improves the way your body responds to sugars
  • Semaglutide is not FDA-approved for weight loss, but may be prescribed if a provider deems it appropriate*
  • 24/7 Provider & Nursing support 
  • Medications, syringes, alcohol swabs 
  • Weight monitoring via app 
  • Shipping delivered to your door  
  • Optional nutritional counseling 

Semaglutide is typically administered as a once-weekly subcutaneous injection, meaning it is injected just under the skin, usually in the abdomen, thigh, or upper arm. It's important to rotate the injection site each week to avoid irritation. Always follow the dosing instructions provided by your healthcare provider, starting with a lower dose and gradually increasing based on your body's response. Be sure to use a clean needle for each injection and dispose of it safely. If you miss a dose, take it as soon as you remember, unless it's less than 48 hours before your next scheduled dose. Never double up on doses. For optimal results, use semaglutide in combination with a healthy diet and regular exercise

Common side effects of semaglutide may include nausea, vomiting, diarrhea, constipation, and abdominal pain, especially when starting treatment. Other possible side effects include fatigue, dizziness, and decreased appetite. In rare cases, semaglutide can cause more serious side effects like pancreatitis, gallbladder issues, or allergic reactions. If you experience severe abdominal pain, difficulty breathing, or swelling of the face or throat, seek medical attention immediately. Always consult your healthcare provider about any side effects or concerns you may have.

* Only available if prescribed after an online consultation with a healthcare provider.
* This page has been medically reviewed
* Actual price to customer will depend on product and subscription plan purchase.

How to get prescribed:

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Simple online consultation

Answer a few questions about your symptoms and health history.

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Connect directly with your provider

A licensed medical provider will determine if treatment is right for you.

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Free, fast and discreet shipping to you

Your ED medication will ship discreetly to you for free, if prescribed.

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Unlimited follow-ups with your provider

Message a provider with questions at any time for free.

Real people, real success.

Jess

Jenna, 37

Lost 40lbs

Catherine

Rachel, 34

Lost 20 lbs

Jen

Emily, 42

Lost 25lbs

Jess

Jenna, 37

Lost 40lbs

"I’ve been on semaglutide for six months now, and it’s been life-changing. My cravings for sweets and snacks have reduced significantly, and I’ve lost about 40 pounds since starting the treatment. The side effects were mild for me—just a bit of nausea in the first couple of weeks, but nothing too disruptive. My doctor has been very supportive, and I feel confident that I’ll be able to keep the weight off long-term."

Catherine

Rachel, 34

Lost 20 lbs

"Semaglutide has been a game changer for me. I’ve struggled with weight for years, and nothing seemed to work until this. I’m three months in and have lost 20 pounds. It’s not just about the weight—I feel like my relationship with food has changed. I no longer feel the constant urge to eat, and I’m able to make healthier choices without feeling deprived. The side effects, like some nausea and bloating, were mild and temporary. I wish I had started this sooner!"
 

Jen

Emily, 42

Lost 25lbs

"After struggling with my weight for years, my doctor recommended semaglutide. I was hesitant at first, but within just a few weeks, I started noticing significant changes. My appetite decreased, and I found it much easier to stick to a healthy diet. I’ve lost 25 pounds over the last four months, and I feel more in control of my eating habits. I did experience some nausea initially, but it was manageable and went away after a couple of weeks. Overall, I’m thrilled with the results and feel healthier than I have in years."